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. 2018 Dec 21;9:5426. doi: 10.1038/s41467-018-07126-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Survival and lymph node metastasis in Tyr::CreER;BRaf^V600E;Phd2^−/− mice. a Kaplan–Meier survival analysis of Tyr::CreER;BRaf^V600E (n = 20), Tyr::CreER;Phd2^−/− (n = 20), Tyr::CreER;BRaf^V600E;Phd2^−/− postnatal mice (n = 20) and Tyr::CreER;BRaf^V600E;Phd2^−/− adult mice (6 weeks, n = 20) after 4-OHT induction. Log rank tests of survival plots of the data indicated a statistically significant difference between the following survival curves: Tyr::CreER; BRaf^V600E; versus Tyr::CreER;BRaf^V600E;Phd2^−/− mice (p < 0.0001), and Tyr::CreER;BRaf^V600E;Phd2^−/− adult versus Tyr::CreER;BRaf^V600E;Phd2^−/− postnatal mice (p < 0.0001). b–d Lymph node metastasis in Tyr::CreER;BRaf^V600E;Phd2^−/− mice. A positive lymph node was present near the area with melanoma induction (arrow points to the lymph node, b). The lymph node was enlarged with pigmented cells (c) and high-power view showed melanoma cells in the lymph node (arrows point to the tumor cells, d). e Percentage of mice that developed lymph node metastasis. Bar in c indicates 200 μm. Bar in d indicates 50 μm. Bar in b indicates 3 mm. *p < 0.05 compared to Tyr::CreER;Braf^V600E;Phd2^−/− group using one-way ANOVA with pairwise comparisons