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. 2018 Dec 21;8:18040. doi: 10.1038/s41598-018-36348-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Peripherally thinned irides in children with Down syndrome (Row A) versus controls (Row B). (Row A) Extensive peripheral iris thinning and absence of contraction furrows in light brown, hazel, and blue irides in children with Down syndrome. Brushfield spots were located between normal and thinned iris. (Row B) Less extensive iris thinning in control children with blue irides, which may not be present in those with darker irides (not shown). (1B,3B) Contraction furrows are present in two children, as are Wölfflin nodules, found at the demarcation between normal and thinned iris.