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. 2018 Oct 4;115(10):1920–1930. doi: 10.1016/j.bpj.2018.10.001

Figure 1.

Figure 1

Comparison of the simulations of the open full-length NavMs structure (PDB: 5HVX) (14) (top), the structure without the voltage sensor (noVSD, middle), and the structure without the C-terminal domain (noCTD, bottom). (a) RMSD comparisons of the trajectories of different segments in the pore domain. The plots are color-coded to match the portions of the structures shown in (b). (b) Snapshots of structures of the full-length (top), noVSD (middle), and noCTD (bottom) constructs at the beginning (0 μs) (left) and end (1 μs) (right) of the simulations with the different regions colored as follows: cyan, S5; yellow, the transmembrane part of S6; red, the C-terminal part of S6; pink, the loop between the C-terminal part of S6 and the coiled-coil; green, coiled-coil. Only two opposite subunits of the tetramer are shown in each case for clarity. (c) Comparisons of the lengths of different segments of S6 at the beginning and end of the simulations of the three different constructs. To see this figure in color, go online.