Table 1.
Five-year survival rate and univariate analysis in patients with chondrosarcoma from 1973–2012.
| Variables | N (%) | Survival (95%CI) | Univariate analysis | |
|---|---|---|---|---|
| HR (95%CI) | P-value | |||
| Year of diagnosis | P < 0.001 | |||
| 1973–1982 | 444 | 64.4(59.9–68.9) | Reference | |
| 1983–1992 | 485 | 69.1(65.0–73.2) | 0.852(0.724–1.001) | 0.052 |
| 1993–2002 | 1109 | 75.3(72.8–77.8) | 0.730(0.628–0.848) | P < 0.001 |
| 2003–2012 | 1699 | 77.6(75.4–79.8) | 0.626(0.533–0.735) | P < 0.001 |
| Sex | P < 0.001 | |||
| Male | 1979 | 70.9(68.7–73.1) | Reference | |
| Female | 1758 | 77.3(75.3–79.3) | 0.746(0.672–0.828) | P < 0.001 |
| Age at diagnosis | P < 0.001 | |||
| 00–24 years | 293 | 87.6 (83.7–91.5) | Reference | |
| 25–49 years | 1420 | 87.5 (85.7–89.3) | 1.448(1.094–1.916) | 0.01 |
| 50–69 years | 1290 | 74.5 (72.0–77.0) | 3.449(2.620–4.541) | P < 0.001 |
| 70 + years | 734 | 40.7 (37.0–44.4) | 10.865(8.223–14.355) | P < 0.001 |
| Race | 0.71 | |||
| White | 3286 | 74.0 (72.4–75.6) | Reference | |
| Black | 238 | 73.8 (67.9–79.7) | 0.976(0.789–1.207) | 0.821 |
| Other | 178 | 70.9 (64.0–77.8) | 1.098(0.868–1.391) | 0.435 |
| CHSDA region | 0.702 | |||
| East | 1088 | 73.6(70.9–76.3) | Reference | |
| Northern Plains | 644 | 69.6(65.9–73.3) | 1.027(0.883–1.194) | 0.73 |
| Pacific Coast | 1641 | 74.8(72.6–77.0) | 0.961(0.846–1.091) | 0.54 |
| Southwest | 359 | 78.5(73.7–82.3) | 0.933(0.771–1.128) | 0.472 |
| Rural or urban | 0.056 | |||
| Rural | 448 | 69.3(64.8–73.8) | Reference | |
| Urban | 3240 | 74.7(73.1–76.3) | 0.863(0.741–1.004) | 0.056 |
| Stage | P < 0.001 | |||
| Localized | 1945 | 86.2(84.6–87.8) | Reference | |
| Regional | 1218 | 67.6(64.9–70.3) | 2.064(1.832–2.325) | P < 0.001 |
| Distant | 302 | 26.5(21.4–31.6) | 7.471(6.386–8.741) | P < 0.001 |
| Grade | P < 0.001 | |||
| Well | 1382 | 87.2 (85.4–89.0) | Reference | |
| Moderately | 1320 | 75.9 (73.5–78.3) | 1.562(1.363–1.791) | P < 0.001 |
| Poorly | 290 | 53.0 (46.9–59.1) | 3.524(2.924–4.247) | P < 0.001 |
| Undifferentiated | 136 | 26.7 (19.1–34.3) | 7.024(5.657–8.720) | P < 0.001 |
| Tumor size | P < 0.001 | |||
| <50 mm | 424 | 89.8 (86.5–93.1) | Reference | |
| 50–79 mm | 308 | 84.1 (79.4–88.8) | 1.400(0.922–2.127) | 0.115 |
| 80–99 mm | 129 | 75.9 (66.9–84.9) | 2.131(1.322–3.434) | 0.002 |
| ≥100 mm | 354 | 61.0 (55.3–66.7) | 4.336(3.089–6.085) | P < 0.001 |
| Laterality | 0.088 | |||
| Right | 1378 | 74.7(72.3–77.1) | Reference | |
| Left | 1292 | 77.9(75.5–80.3) | 0.894(0.786–1.017) | 0.088 |
| Primary site-lableled | P < 0.001 | |||
| Upper limb | 691 | 83.7 (80.8–86.6) | Reference | |
| Lower limb | 1201 | 77.1 (74.6–79.6) | 1.224(1.040–1.441) | 0.015 |
| Skull and mandible | 305 | 84.7 (80.4–89.0) | 1.048(0.817–1.343) | 0.714 |
| Chest bones | 612 | 79.0 (75.7–82.3) | 1.366(1.134–1.645) | 0.001 |
| Vertebral and pelvic bones | 853 | 56.0 (52.5–59.5) | 2.273(1.932–2.675) | P < 0.001 |
| Surgery | P < 0.001 | |||
| Yes | 3177 | 79.7(78.3–81.1) | Reference | |
| No | 488 | 41.5(37.0–46.0) | 3.392(2.994–3.842) | P < 0.001 |
| Surgery type | P < 0.001 | |||
| No surgery | 338 | 43.0(37.3–48.7) | Reference | |
| Local excision | 856 | 87.4(85.0–89.8) | 0.176(0.142–0.218) | P < 0.001 |
| Radical excision | 886 | 82.4(79.7–85.1) | 0.216(0.176–0.265) | P < 0.001 |
| Amputation | 239 | 62.7(56.0–69.3) | 0.470(0.368–0.600) | P < 0.001 |
| Radiation | P < 0.001 | |||
| Yes | 459 | 49.9 (45.2–54.6) | Reference | |
| No | 3203 | 77.6 (76.0–79.2) | 0.416(0.365–0.475) | P < 0.001 |
| Treatment | P < 0.001 | |||
| Surgery + radiation | 328 | 63.1(057.6–68.6) | Reference | |
| Radiation | 113 | 17.3(10.0–24.6) | 4.291(3.339–5.514) | P < 0.001 |
| Surgery | 2793 | 81.8(80.2–83.4) | 0.521(0.440–0.617) | P < 0.001 |
| None | 365 | 49.1(43.8–54.4) | 1.538(1.253–1.889) | P < 0.001 |
P values calculated by univariate analysis. Bold represents statistical significance, P < 0.05.
HR: hazard ratio; CI: confidence interval.