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. 2018 Dec 14;8(12):e022879. doi: 10.1136/bmjopen-2018-022879

Figure 2.

Figure 2

Risk of bias summary of 12 included studies. The green background with ‘+’ means low risk of bias; the red background with ‘-’ means high risk of bias; the yellow background with ‘?’ means unknown risk of bias. Trials involving three or more high risks of bias were considered as poor methodological quality.