Table 1.

Time schedule of enrolment, interventions, assessments and visits for participants

Assessment			Screening and randomisation visits		Follow-up visits									Unscheduled
			Screening period (Baseline)	Randomisation	Follow-up 1	Follow-up 2	Follow-up 3	Follow-up 4	Follow-up 5	Follow-up 6	Follow-up 7	Follow-up 8	Follow-up 9 (Final)	Premature discontinuation
			Week −4 to −1	Week 0	Month 3	Month 6	Month 12	Month 18	Month 24	Month 30	Month 36	Month 42	Month 48
Selection criteria			X	X
Informed consent			X
Clinical history			X
Physical examination			X
BP measures	Group 1	Office BP	X	X	X	X	X	X	X	X	X	X	X	X
		Home BP	X				X						X	X
		24 hours ABPM	X				X		X		X		X	X
	Group 2	Office BP	X	X	X	X	X	X	X	X	X	X	X	X
		Home BP	X				X						X	X
		24 hours ABPM	X		X	X	X	X	X	X	X	X	X	X
Blood sample for serum creatinine					X	X
Blood sample for serum creatinine, glucose, HbA1c, uric acid, Na+, K+, lipids			X				X		X		X		X	X
ECG			X			X	X		X		X		X	X
Echocardiogram			X				X		X		X		X	X
Urine sample for microalbuminuria and albumin:creatinine ratio			X			X	X		X		X		X	X
Ascertain achievement of BP control/adjust antihypertensive treatment if needed				X	X	X	X	X	X	X	X	X	X	X
Registration of antihypertensive therapy			X	X	X	X	X	X	X	X	X	X	X	X
Registration of concomitant medication			X	X	X	X	X	X	X	X	X	X	X	X
Adverse events/safety evaluation					X	X	X	X	X	X	X	X	X	X
Blood sample for biobank creation					X		X

ABPM, ambulatory blood pressure monitoring; BP, blood pressure; HbA1c, glycated haemoglobin.