Table 3.

Adjusted multivariate odds of neoplastic progression for the multibiomarker panel

	Progressors	Nonprogressors	Adjusted† OR
Marker	n (%)	n (%)
Expert dysplasia‡
No LGD	79 (87)	108 (99)	1 (referent)
LGD	12 (13)	1 (1)	35.7 [1.4, 920.8]
p53
Negative	53 (58)	88 (81)	1 (referent)
Abnormal	38 (42)	21 (19)	4.1 [1.4, 12.4]
p53 three groups
Wild type	53 (58)	88 (81)	1 (referent)
Absent staining	6 (7)	2 (2)	5.4 [0.3, 85.7]
Overexpression	32 (36)	19 (17)	2.8 [1.2, 12.7]
AOL‡
0 compartments abnormal	18 (20)	34 (31)	1 (referent)
1 compartments abnormal	29 (32)	43 (39)	0.9 [0.3, 2.4]
2 compartments abnormal	28 (31)	25 (23)	1.7 [0.6, 5.1]
3 compartments abnormal	16 (18)	7 (6)	4.3 [0.7, 26.3]
Model performance‡
C statistic			0.73

^†Adjustments were made for current tobacco and alcohol use, BE segment length and time in follow-up;

^‡Estimates are presented for the model with two groups of p53 expression.