Figure 1.

Schematic depiction and phylogenetic analysis of the HDACs of BPH. (a) Schematic depiction of the HDAC members of BPH. The catalytic domain of deacetylase activity is shown by boxes in red or blue. The zinc finger domain of NlHDAC6 is shown by a purple box. The length of the open reading frame of each gene is shown on the right. (b) Phylogenetic analysis of the HDAC members of BPH. The phylogenetic tree was constructed based on 70 HDACs from 19 species (see Material and methods) using the maximum-likelihood method, and bootstraps were set with 1000 replications. The HDAC members of BPH are in bold.