Table 4.
Predictors of nasopharyngeal defect re-epithelialization of patients with postradiation nasopharyngeal necrosis but with negative pathology for tumor recurrence at the time of surgery
| Clinical characteristic | Total [cases (%)] | Status of the re-epithelialization [cases (%)] | Univariate logistic regression analysis | ||
|---|---|---|---|---|---|
| Survived | Necrotized | P-value | OR (95% CI) | ||
| Gender | 0.232 | 2.444 (0.565–10.570) | |||
| Female | 13 (25.0) | 9 (21.4) | 4 (40) | ||
| Male | 39 (75.0) | 33 (78.6) | 6 (60) | ||
| Age (years) | 0.405 | 0.551 (0.135–2.241) | |||
| < 51 | 25 (48.1) | 19 (45.2) | 6 (60) | ||
| ≥ 51 | 27 (51.9) | 23 (54.8) | 4 (40) | ||
| Cycles of radiotherapy | 0.022 | 5.500 (1.272–23.782) | |||
| One | 37 (71.2) | 33 (78.6) | 4 (40) | ||
| Two | 15 (28.8) | 9 (21.4) | 6 (60) | ||
| Necrosis-free interval | 0.296 | 3.194 (0.362–28.180) | |||
| Acute necrosis | 12 (23.1) | 11 (26.2) | 1 (10) | ||
| Chronic necrosis | 40 (76.9) | 31 (73.8) | 9 (90) | ||
| Carotid artery exposure | 0.978 | 0.980 (0.240–4.004) | |||
| Yes | 31 (56.9) | 25 (59.5) | 6 (60) | ||
| No | 21 (40.4) | 17 (40.5) | 4 (40) | ||
| Osteoradionecrosis | 0.173 | 4.500 (0.517–39.149) | |||
| Yes | 37 (71.2) | 28 (66.7) | 9 (90) | ||
| No | 15 (28.8) | 14 (33.3) | 1 (10) | ||
| Status of the flap | < 0.001 | 180.000 (14.672–2208.254) | |||
| Survived | 41 (78.8) | 40 (95.2) | 1 (10) | ||
| Necrotized | 11 (21.2) | 2 (4.8) | 9 (90) | ||
OR odds ratio, CI confidence interval