Table 5.
Cox univariate and multivariate analyses of the prognostic factors related to overall survival (OS) for the patients with postradiation nasopharyngeal necrosis
| Clinical characteristic | 2-year OS rate (%) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| P value | HR (95% CI) | P value | HR (95% CI) | ||
| Gender | 0.601 | 1.295 (0.491–3.412) | |||
| Female | 84.0 | ||||
| Male | 76.0 | ||||
| Age (years) | 0.331 | 1.589 (0.625–4.039) | |||
| < 51 | 84.7 | ||||
| ≥ 51 | 72.7 | ||||
| Cycles of radiotherapy | 0.717 | 1.197 (0.453–3.163) | |||
| One | 80.8 | ||||
| Two | 71.9 | ||||
| Necrosis-free interval | 0.617 | 1.372 (0.397–4.737) | |||
| Acute necrosis | 86.3 | ||||
| Chronic necrosis | 75.7 | ||||
| Carotid artery exposure | 0.817 | 1.122 (0.423–2.975) | |||
| Yes | 68.6 | ||||
| No | 82.1 | ||||
| Osteoradionecrosis | 0.607 | 0.782 (0.308–1.991) | |||
| Yes | 81.2 | ||||
| No | 71.4 | ||||
| Postoperative pathological result | 0.001 | 5.026 (1.974–12.799) | 0.001 | 5.018 (1.970–12.782) | |
| Negative | 88.4 | ||||
| Positive | 54.2 | ||||
| Status of the flap | 0.055 | 2.467 (0.982–6.195) | 0.056 | 2.442 (0.978–6.099) | |
| Survived | 80.3 | ||||
| Necrotized | 68.8 | ||||
OS overall survival, HR hazard ratio, CI confidence interval