Table 4.
Previously reported genes and microRNAs related to OPLL
| Year | First author | Country | Gene | Chromosome | Location |
|---|---|---|---|---|---|
| 2002 | Ogata | Japanese | IL-1β | 2q14 | Spine |
| 2018 | Wang | Chinese | IL17RC | 3p25.3 to 3p24.1 | Thoracic |
| 1999 | Numasawa | Japanese | RXRB | 6p21 | Spine |
| 1998 | Koga | Japanese | COL11A2 | 6p21 | Spine |
| 2010 | Liu | Chinese | RUNX2 | 6p21 | Spine |
| 1999 | Nakamura | Japanese | NPPS | 6q22-q23 | Spine |
| 2002 | Ogata | Japanese | ESR1 | 6q25 | Spine |
| 2016 | Nakajima | Japanese | Rspo2 | 8q23.1 | Spine |
| 2014 | Wei | Chinese | PTCH1 | 9q22.23 | Cervical |
| 2011 | Kim | Korean | IL15RA | 10p15 | Spine |
| 2012 | Ren | Chinese | BMP9 | 10q11.22 | Cervical |
| 2014 | Wei | Chinese | COL17A1 | 10q24.3-10q25.1 | Cervical |
| 2008 | Kobashi | Japanese | VDR | 12q13 | Spine |
| 2006 | Horikoshi | Japanese | TGFβ3 | 14q24 | Spine |
| 2002 | Furushima | Japanese | BMP4 | 14q22 | Spine |
| 2001 | Kamiya | Japanese | TGFβ1 | 19q13 | Cervical |
| 2008 | Wang | Chinese | BMP2 | 20p12.3 | Cervical |
| 2003 | Tanaka | Japanese | COL6A1 | 21q22.3 | Spine |
| 2018 | Wang | Chinese | COL6A1 | 21q22.3 | Thoracic |
| 2014 | Chon | Korean | BID | 22q11 | Cervical |
| 2016 | Lim | Korean | miR-146a | Cervical | |
| miR-149 | Cervical | ||||
| miR-196a2 | Cervical | ||||
| miR-499 | Cervical | ||||
| 2016 | Xu | Chinese | miR-10a-5p | Cervical | |
| miR-563 | Cervical | ||||
| miR-885-5p | Cervical | ||||
| Present | Liang | Chinese | COL6A6 | 3q22.1 | Thoracic |
| COL9A1 | 6q13 | Thoracic | |||
| TLR1 | 4p14 | Thoracic |