Fig. 2.

Differential expression of PBMC miRNAs between SLE patients and healthy controls in the exploratory cohort. a Volcano plot of differentially expressed miRNAs. The blue spots indicate significantly downregulated miRNAs, and the red spots indicate significantly upregulated miRNAs. b Hierarchical clustering of the differentially expressed miRNAs. Red represents relatively highly expressed miRNAs, and blue represents relatively lowly expressed miRNAs. c Gene ontology (GO) analysis of differentially expressed miRNAs. Red indicates biological process (BP), green indicates molecular function (MF), and blue indicates cellular component (CC). d Pathways of the target genes of differentially expressed miRNAs. The vertical axis indicates the pathway term, and the horizontal axis indicates the richness factor. The size of the spots represents the number of target genes of differentially expressed miRNAs, and the color of the spots represents the Q-value