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. 2018 Dec 22;6:155. doi: 10.1186/s40425-018-0477-9

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Forest plot of hazard ratios in subgroup-analyses comparing overall survival in patients who received IO-Chemotherapy vs Chemotherapy alone. The horizontal line crossing the dot represents the 95%CI of the pooled hazard ratio in each subgroup-analysis. No. of trials refers to the number of trials included in each subgroup-analysis. I² (P) shows the heterogeneity in each subgroup meta-analysis. P (subgroups) demonstrates the significance of differences between the subgroups. HR, hazard ratio; CI, confidence interval; ECOG PS, Eastern Cooperative Oncology Group performance status; EGFR, epidermal growth factor receptor; ALK, Anaplastic lymphoma kinase; PD-1, programmed cell death 1; PD-L1, programmed cell death 1 ligand 1; IO, Immuno-oncology