Fig. 1.

shows ensemble-level clonal evolution trajectories in colorectal cancer using CAPRI algorithm. The events of the model are connected by dashed lines where red dotted lines denote hard and orange denotes soft exclusivity. Algorithm uses both Bayesian information criterion ‘BIC’ and Akaike information criterion ‘AIC’ as a regularization. Non-parametric bootstrap scores (NPB) are shown in the figure with hypergeometric test p-value cutoff of < 0.05. Other relations including temporal priority, probability raising are shown in Fig. 1a, b, and c and reported data in Additional file 4. 1a) clonal evolution in RCC, 1b) clonal evolution in LCC and 1c) clonal evolution in rectal cancers