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. 2018 Dec 19;12:101–111. doi: 10.2147/OTT.S182657

Figure 5.

Figure 5

SNHG15 contributes to the chemoresistance of EOC cells.

Notes: (A) The inhibition rate of cisplatin on A2780 cells and A2780-R cells were detected by MTT assay. (B) The inhibition rate of cisplatin on SKOV3 cells and SKOV3-R cells were detected by MTT assay. (C) Expression of SNHG15 in A2780 cells and A2780-R cells was detected by qRT-PCR assay. (D) Expression of SNHG15 in SKOV3 cells and SKOV3-R cells was detected by qRT-PCR assay. (E) Inhibition rates of cisplatin on A2780 cells transfected with SNHG15 overexpression plasmid and empty vector after cisplatin treatment were measured by MTT assay. (F) Inhibition rates of cisplatin on SKOV3 cells transfected with SNHG15 siRNAs and siNC after cisplatin treatment were measured by MTT assay. *P<0.05 and **P<0.01.

Abbreviations: A2780-R, cisplatin-resistant A2780 cells; EOC, epithelial ovarian cancer; SKOV3-R, cisplatin-resistant SKOV3 cells; siNC, nontargeting control siRNAs.