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. 2018 Jul 16;10(6):527–538. doi: 10.1093/jmcb/mjy040

Figure 4.

Figure 4

LRIF1–HP1α interaction is essential for accurate mitosis. (A) Real-time imaging of chromosome movement in cells expressing LRIF1 siRNA and RNAi-resistant GFP-LRIF1 FL (full-length) or its mutant GFP-LRIF1 FLM (full-length mutant). To visualize chromosome movement with a DeltaVision system, cells were co-transfected with mCherry-H2B. Scale bar, 10 μm. (B) Statistical analysis of chromosome bridges in A. At least 26 cells per group (n = 30, LRIF1 FL; n = 26, LRIF1 FLM) were examined from three independent experiments. (C) Statistical analysis of mitotic delay judged by the intervals between NEBD and anaphase onset in A (n = 30, LRIF1 FL; n = 26, LRIF1 FLM). Data represent mean ± SEM and statistical significance was tested by two-sided t-test and represented by asterisks corresponding to *P < 0.05, **P < 0.01.