Table 2.
Diagnostic performance of the BDG detection assay at different cutoff values
| BDG test performance | Values of BDG cutoff (pg/mL) used to calculate the indicated parameters | ||||
|---|---|---|---|---|---|
| 80 | 200 | 300 | 400 | >500 | |
| Sensitivity (%) | 91.0 | 76.4 | 68.5 | 64.0 | 60.7 |
| Specificity (%) | 87.7 | 94.9 | 96.1 | 97.2 | 97.8 |
| PPV (5) | 38.2 | 53.5 | 57.5 | 64.0 | 68.3 |
| NPV (5) | 99.1 | 98.1 | 97.5 | 97.2 | 97.0 |
| Area under the ROC curve (95% CI) | 0.89 (0.86–0.93) | 0.86 (0.81–0.90) | 0.82 (0.77–0.88) | 0.81 (0.75–0.86) | 0.79 (0.73–0.85) |
Abbreviations: BDG, (1,3)-β-D-glucan; NPV, negative predictive value; PPV, positive predictive value; ROC, receiver operating characteristic.