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. 2018 Dec 20;14:101–117. doi: 10.2147/IJN.S173954

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© 2019 Shen et al. This work is published and licensed by Dove Medical Press Limited

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In vivo fluorescence imaging efficacy.

Notes: Fluorescence images of glioma-bearing nude mice at different times after tail vein injection of free ICG and SPIO@DSPE-PEG/DOX/ICG NPs (A); arrow indicates direction of the glioma. Ex vivo fluorescence images (B) and quantitative analysis (C) of main organs from glioma-bearing nude mice after 72 hours of tail vein injection. Data are mean ± SD, n=3, ^*P<0.05, ^**P<0.01 vs flurensence intensity in tumor.

Abbreviations: DOX, doxorubicin; DSPE-PEG, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)]; ICG, indocyanine green; SPIO NPs, superparamagnetic iron oxide nanoparticles.