Table 1.
The main PK parameters of CPT-11 injection and SN38-PA liposome in Sprague Dawley rats after i.v. injection
| Parameters | CPT-11 injection
|
SN38-PA liposome
|
||
|---|---|---|---|---|
| CPT-11 | SN38 | SN38-PA | SN38 | |
|
| ||||
| Cmax (µg/L) | 8,057.32±1,564.55 | 1,582.55±144.13 | 72,367.32±13,357.05 | 11,855.09±1,170.74 |
| AUClast (µg/L⋅h) | 5,342.03±748.75 | 2,408.82±185.20 | 142,550.10±9,127.45 | 23,884.39±4,289.21 |
| t1/2 (hours) | 5.33±1.55 | 4.98±0.96 | 2.49±2.36 | 6.65±2.87 |
| CL (L/h/kg) | 2.93±0.39 | 6.43±0.58 | 0.11±0.01 | 0.66±0.11 |
| V (L/kg) | 22.43±7.23 | 45.68±5.58 | 0.40±0.35 | 6.16±2.60 |
Note: Values are non-compartmental model parameter estimates.
Abbreviations: AUClast, area under the curve computed to the last time point; CL, total body clearance; Cmax, maximum plasma concentration of drug; i.v., intravenous; PK, pharmacokinetics; V, volume of distribution; SD, Sprague Dawley; t1/2, elimination half-life.