Table 2.
Pharmacokinetic parameters in tissues after i.v. administration of CPT-11 injection and SN38-PA liposome in SD rats, respectively
| Parameters | Tissues | CPT-11 | SN38-PA | SN38 converted from CPT-11 | SN38 converted from SN38-PA |
|---|---|---|---|---|---|
|
| |||||
| AUC (ng/g⋅h) | Heart | 3,445.15±1,212.62 | 1,885.87±446.35 | 204.36±86.84 | 159,040.61±47,367.08 |
| Liver | 8,523.25±701.18 | 86,942.86±16,809.80 | 1,668.52±254.34 | 161,175.00±5,097.05 | |
| Spleen | 14,233.87±2,291.03 | 50,099.94±4,361.25 | 85.46±19.24 | 231,699.99±15,722.04 | |
| Lung | 6,124.99±595.70 | 526.07±606.16 | 641.41±315.69 | 276,069.81±68,869.66 | |
| Kidney | 8,678.19±2,252.09 | 818.81±195.96 | 1,906.72±176.87 | 85,395.87±10,320.78 | |
| Rectum | 24,522.86±3,108.34 | 1,831.71±1,174.77 | 1,523.76±462.66 | 40,399.18±4,973.90 | |
| Tumor | 10,573.85±2,629.70 | 14,897.85±3,286.07 | 1,298.28±248.72 | 193,729.60±4,967.34 | |
| Cmax (ng/g) | Heart | 6,043.35±616.58 | 4,556.66±806.70 | 90.74±16.79 | 44,257.14±2,564.53 |
| Liver | 6,050.50±1,275.10 | 20,009.70±3,323.64 | 438.69±119.71 | 33,676.18±4,664.01 | |
| Spleen | 6,144.39±613.06 | 19,275.82±2,327.95 | 112.57±57.71 | 52,060.62±10,148.47 | |
| Lung | 7,929.60±2,346.87 | 1,074.44±1,033.97 | 204.82±63.22 | 49,853.18±12,422.62 | |
| Kidney | 9,007.81±3,574.08 | 2,433.49±123.16 | 875.63±171.05 | 22,073.00±4,791.17 | |
| Rectum | 26,599.03±4,804.94 | 2,817.60±2,144.32 | 641.43±30.95 | 18,074.06±4,367.29 | |
| Tumor | 6,496.83±512.72 | 4,317.47±1,368.18 | 362.59±107.06 | 47,330.80±8,179.95 | |
Abbreviations: i.v., intravenous; SD, Sprague Dawley.