Table 3.
The in vivo efficiency of different formulation against S180 solid tumor in mice
| Groups | Dose (mg/kg) | BW (g)
|
TW (g) | TIR (%) | |
|---|---|---|---|---|---|
| Start | End | ||||
|
| |||||
| Saline | / | 17.55±0.95 | 33.92±1.99 | 2.10±0.54 | 0 |
| CPT-11 injection | 15.88 | 17.50±0.62* | 28.86±1.61*** | 0.88±0.27*** | 58.17 |
| SN38-PA liposome | 8.03 | 17.52±0.72* | 29.19±1.87**,& | 0.56±0.16***,&& | 73.25 |
| SN38-PA liposome | 16.06 | 17.65±0.51* | 27.77±3.26**,& | 0.14±0.06***,&&& | 93.49 |
| SN38-PA liposome | 32.12 | 17.58±1.29* | 26.68±1.03***,&& | 0.05±0.03***,&&& | 97.7 |
Notes: Data are presented as mean ± SD (n=6).
*
P>0.05,
**
P<0.05, and
***
P<0.01, compared with saline;
&
P>0.05,
&&
P<0.05, and
&&&
P<0.01, compared with CPT-11 injection.
Abbreviations: BW, body weight; TW, tumor weight; TIR, tumor inhibition rate.