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Cross‐reactivity of swine sera raised against antigenic cluster representatives. Relative fold reduction in heterologous strains from antisera raised to MN/09 (Cyan), NY/11 (Red), and IA/14 (Green). A ≥ 8‐fold reduction in the heterologous GMT from the homologous reaction is considered a significant loss in cross‐reactivity by the sera. The dominant antigenic motif is indicated for colored phenotypes
