Table 2.
Profiling of urinary SBAs in women with normal pregnancy, mild ICP, and severe ICP (in peak area ratios of SBA and IS).
| SBAs | Normal pregnancy | ICP |
|
|---|---|---|---|
| Mild ICP | Severe ICP | ||
| 3S-LCA | 0.001 (0.000,0.001) | 0.001 (0.000,0.002) | 0.002 (0.001,0.006) |
| di-BA-S-1 | 0.028 (0.011, 0.060) | 0.098 (0.038, 0.143)a | 0.130 (0.037, 0.474)b |
| di-BA-S-2 | 0.009 (0.003, 0.032) | 0.023 (0.018, 0.056) | 0.181 (0.021, 5.374)b |
| di-BA-S-3 | 0.045 (0.018, 0.135) | 0.180 (0.101, 0.244) | 0.216 (0.092, 0.385)b |
| CA-3S | 0.090 (0.002, 0.864) | 1.849 (1.725, 2.044)a | 1.870 (1.198, 3.514)b |
| GLCA-3S | 0.201 (0.084 0.442) | 0.403 (0.213, 1.094) | 1.827 (0.243, 3.846)b |
| di-GBA-S-1 | 0.371 (0.117, 1.609) | 1.204 (0.515, 2.219) | 10.524 (0.892, 44.205)b |
| di-GBA-S-2 | 0.097 (0.046, 0.154) | 0.667 (0.239, 1.002)a | 0.766 (0.247, 1.746)b |
| di-GBA-S-3 | 0.552 (0.263, 1.124) | 5.903 (2.755, 6.587)a | 11.932 (5.989, 16.967)b,c |
| di-GBA-S-4 | 1.028 (0.428, 2.698) | 4.540 (2.184, 7.604)a | 9.513 (4.945, 18.579)b,c |
| GCA-3S | 0.077 (0.047, 0.215) | 1.457 (1.115, 3.326)a | 7.604 (3.679, 10.432)b,c |
| TLCA-3S | 0.111 (0.034, 0.211) | 0.348 (0.139, 0.498)a | 1.905 (0.292, 3.775)b |
| di-TBA-S-1 | 0.124 (0.036, 0.286) | 0.978 (0.299, 1.597)a | 1.861 (0.876, 23.245)b |
| di-TBA-S-2 | 0.208 (0.081, 0.407) | 3.616 (1.483, 4.424) | 12.563 (4.344, 22.159)b,c |
| di-TBA-S-3 | 0.499 (0.281, 1.252) | 3.142 (0.968, 5.543) | 7.881 (5.628, 13.853)b,c |
| TCA-3S | 0.070 (0.016, 0.137) | 1.350 (0.609, 2.446)a | 8.980 (2.492, 17.224)b,c |
| Total unconjugated SBA | 0.287 (0.095, 0.960) | 2.137 (1.884, 2.341)a | 3.606 (2.274, 7.949)b,c |
| Total GBA-S | 3.101 (1.242, 5.184) | 16.950 (11.396, 20.956)a | 55.520 (36.387, 80.127)b,c |
| Total TBA-S | 1.165 (0.689, 2.072) | 9.945 (6.983, 20.455)a | 50.240 (27.473, 74.890)b,c |
| Total SBAs | 4.938 (3.271, 7.992) | 29.407 (22.429, 38.275)a | 100.866 (80.760,178.595)b,c |
Results are expressed as median ((25th and 75th percentiles)). Wilcoxon test was used to assess the significance of difference between groups.
a
Means significantly different from the group of normal pregnancy.
b
Means significantly different from the group of normal pregnancy.
c
Means significantly different from the group of mild ICP.