Table 3.

Potential biomarkers discovered by VIP value and ROC analysis.

Biomarkers	VIP	AUC	p	Sensitivity (%)		Specificity (%)	Youden index	+LR	-LR	Cut-off
Normal-ICP
di-GBA-S-3	1.38	0.975	<0.0001		96.6	90.9	0.875	10.6	0.04	1.66
GCA-3S	1.37	0.997	<0.0001		100	95.5	0.955	22.0	0	0.49
di-TBA-S-3	1.30	0.929	<0.0001		86.2	100	0.862	–	0.14	1.60
di-TBA-S-2	1.25	0.983	<0.0001		96.6	100	0.966	–	0.03	0.93
TCA-3S	1.24	0.995	<0.0001		100	95.5	0.955	22	0	0.37
CA-3S	1.16	0.873	<0.0001		79.3	95.5	0.748	17.5	0.22	1.21
TLCA-3S	1.05	0.828	<0.0001		69.0	90.9	0.599	7.59	0.34	0.34
Mild-severe ICP
di-GBA-S-3	1.40	0.773	0.0031		72.2	90.9	0.631	7.94	0.31	6.90
GCA-3S	1.36	0.874	<0.0001		77.8	90.9	0.687	8.56	0.24	3.46
di-TBA-S-2	1.30	0.768	0.0041		77.8	81.8	0.596	4.28	0.27	4.42
di-TBA-S-3	1.29	0.884	<0.0001		83.3	90.9	0.742	9.17	0.18	5.63
TLCA-3S	1.27	0.763	0.0057		72.2	90.9	0.631	7.94	0.31	0.67
TCA-3S	1.19	0.803	0.0003		77.8	81.8	0.596	4.28	0.27	2.45
di-BA-S-2	1.04	0.707	0.0331		50	90.9	0.409	5.5	0.55	0.25
di-GBA-S-1	1.03	0.717	0.025		72.2	72.7	0.450	2.65	0.38	1.33