Table 2.
Univariable and multivariable risk factors influencing post hematopoietic stem cell transplant outcome
| Univariable HR (95%CI; P value) | Multivariable HR (95%CI; P value) | ||
| PFS | Age at HCT | 1.5 (0.27-6; P = 0.6) | |
| B-cell vs T-cell | 0.53 (0.25-1.17; P = 0.11) | ||
| ALL vs LBL | 0.6 (0.27-1.45; P = 0.24) | ||
| Female D → male R | 0.87 (0.25-2.26; P = 0.79) | ||
| Donorgender mismatch | 0.53 (0.22-1.17; P = 0.12) | ||
| MSD vs other | 0.5 (0.22-1.28; P = 0.14) | ||
| TBI regimen | 1.1 (0.41-3.67; P = 0.89) | ||
| MAC vs RIC/NMA | 1.37 (0.41-8.5; P = 0.65) | ||
| CR1 vs other | 0.59 (0.28-1.28; P = 0.18) | ||
| aGVHD | 2.1 (0.95-4.5; P = 0.066) | 3.14 (1.36-7.1; P = 0.008) | |
| cGVHD | 0.43 (0.18-0.94; P = 0.033) | 0.38 (0.15-0.89; P = 0.026) | |
| OS | Age at HCT | 1.02 (0.98-1.05; P = 0.28) | |
| B-cell vs T-cell | 0.57 (0.24-1.37; P = 0.2) | ||
| ALL vs LBL | 0.44 (0.19-1.11; P = 0.08) | ||
| Female D → male R | 1.15 (0.33-3.1; P = 0.8) | ||
| Donorgender mismatch | 0.62 (0.23-1.48; P = 0.29) | ||
| MSD vs other | 1.27 (0.43-5.4; P = 0.69) | ||
| TBI regimen | 1.99 (0.58-12.5; P = 0.31) | ||
| MAC vs RIC/NMA | 0.69 (0.23-2.92; P = 0.56) | ||
| CR1 vs other | 0.5 (0.21-1.17; P = 0.11) | ||
| aGVHD | 3.35 (1.42-7.9; P = 0.006) | 4.9 (1.99-12; P = 0.0007) | |
| cGVHD | 0.4 (0.15-0.97; P = 0.043) | 0.29 (0.1-0.67; P = 0.0044) | |
HCT: Hematopoietic stem cell transplant; ALL: Acute lymphoblastic leukemia; LBL: Lymphoblastic lymphoma; Ph: Philadelphia chromosome; MSD: Matched sibling donor; TBI: Total body irradiation; CR: Complete remission; MAC: Myeloablative conditioning; RIC/NMA: Reduced intensity conditioning/no myeloablative; a/cGVHD: Acute/chronic graft vs host disease.