Table 2.
Percent distribution of AQP2-positive, [H+]-ATPase-positive or double negative cells in the cortical and medullary collecting ducts of WT or P2Y2 KO mice fed control or lithium-added diets for 5 months.
| Group | AQP2-positive | [H+]-ATPase-positive | Double negative |
|---|---|---|---|
| Cortex | |||
| WT-CT | 66.61 ± 1.98 (3) | 32.51 ± 1.28 (3) | 0.88 ± 0.88 (3) |
| WT-LI | 55.30 ± 3.16 (4)* | 44.48 ± 3.15 (4)** | 0.22 ± 0.22 (4) |
| KO-CT | 65.96 ± 4.24 (3) | 33.14 ± 3.59 (3) | 0.90 ± 0.90 (3) |
| KO-LI | 69.27 ± 2.38 (4) | 29.84 ± 1.79 (4) | 0.89 ± 0.64 (4) |
| Medulla | |||
| WT-CT | 88.20 ± 1.80 (6) | 11.43 ± 1.87 (6) | 0.38 ± 0.18 (6) |
| WT-LI | 61.80 ± 3.10 (5)‡ | 37.77 ± 3.28 (5)‡‡ | 0.46 ± 0.18 (5) |
| KO-CT | 85.70 ± 1.80 (4) | 13.73 ± 1.72 (4) | 0.60 ± 0.21 (4) |
| KO-LI | 82.20 ± 2.20 (7) | 17.29 ± 2.13 (7) | 0.48 ± 0.14 (7) |
Results are presented as mean ± SE of percentage values for each cell type. The numbers in the parenthesis show the number of mice examined in each group. Statistical analysis: one-way ANOVA: ∗significantly different from the corresponding value in the WT-CT group (P < 0.05) or KO-LI group (P < 0.05). ∗∗Significantly different from the corresponding value in the WT-CT group (P < 0.05) or KO-LI group (P < 0.01). ‡Significantly different from the corresponding value in the WT-CT group (P < 0.001) or KO-LI group (P < 0.001). ‡‡Significantly different from the corresponding value in the WT-CT group (P < 0.001) or KO-LI group (P < 0.001). For the results of two-way ANOVA refer to Table 1.