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. 2018 Nov 20;14:52–66. doi: 10.1016/j.omtn.2018.11.002

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© 2018 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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MDA5 Activation by PLA in Muscle Tissue

Representative images of MDA5-MAVS PLA (white) 16 hr following i.m. injection into the anterior tibialis of 10 μg luciferase IVT mRNA (red) unformulated or formulated with CholK. Extended focus images are shown. Scale bars, 20 μm (full images) and 5 μm (crops). White boxes show cropped selection. Quantification of MDA5-MAVS PLA is shown. Statistics were performed with a two-way ANOVA with a Tukey’s multiple comparisons test, where n = 30 and ****p < 0.0001. 95% confidence intervals are shown in black.