Table 2. Survival outcomes.
| Variables | DFS | OS | CSS | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate Analysis | Univariate analysis | Multivariate Analysis | Univariate analysis | Multivariate Analysis | |||||||||||||
| HR | 95% CI | p | HR | 95% CI | p | HR | 95% CI | p | HR | 95% CI | p | HR | 95% CI | p | HR | 95% CI | p | |
| Age >75 yr | 1.93 | 1.06–3.53 | 0.033 | 1.73 | 0.76–3.96 | 0.19 | 2.78 | 1.24–6.26 | 0.013 | 1.13 | 0.36–3.51 | 0.84 | 3.69 | 1.61–8.47 | 0.002 | 1.65 | 0.47–5.79 | 0.44 |
| Obesity (BMI >30) | 0.34 | 0.11–1.01 | 0.09 | - | 0.56 | 0.13–2.50 | 0.45 | - | 0.52 | 0.12–2.31 | 0.40 | - | ||||||
| Positive node patients | 2.53 | 1.24–5.16 | 0.011 | - | 2.78 | 1.09–7.08 | 0.04 | - | 2.32 | 0.86–6.24 | 0.095 | - | ||||||
| Positive nodes >2 | 3.03 | 1.48–6.22 | 0.003 | 8.94 | 2.67–29.97 | <0.001 | 3.40 | 1.33–8.67 | 0.01 | 7.72 | 2.05–28.98 | 0.002 | 3.02 | 1.11–8.20 | 0.03 | 5.25 | 1.45–19.05 | 0.012 |
| Size of lesion (mm) | 0.99 | 0.84–1.19 | 0.99 | - | 1.02 | 0.81–1.30 | 0.88 | - | 1.00 | 0.79–1.28 | 0.99 | - | ||||||
| Positive margins | 1.57 | 0.77–3.22 | 0.22 | - | 1.76 | 0.68–4.56 | 0.25 | - | 0.99 | 0.35–2.78 | 0.98 | - | ||||||
| Grade 3 | 1.71 | 0.86–3.40 | 0.13 | - | 1.33 | 0.52–3.41 | 0.55 | - | 1.57 | 0.63–3.90 | 0.33 | - | ||||||
| Stage | 1.40 | 1.04–1.79 | 0.026 | 1.59 | 0.94–1.95 | 0.42 | 1.28 | 0.35–4.71 | 0.07 | 0.82 | 0.42–1.58 | 0.54 | 1.25 | 0.27–5.75 | 0.08 | 0.78 | 0.30–1.44 | 0.30 |
| NACT | 1.34 | 0.54–3.41 | 0.54 | - | 0.34 | 0.049–3.89 | 0.14 | - | 0.51 | 0.07–3.85 | 0.52 | - | ||||||
| Adjuvant therapy | 1.14 | 0.77–1.71 | 0.51 | - | 1.13 | 0.60–2.13 | 0.70 | - | 0.96 | 0.47–1.96 | 0.91 | - | ||||||
| ACCI | 1.80 | 1.19–2.72 | 0.005 | 3.04 | 1.54–5.99 | <0.001 | 3.93 | 1.86–8.31 | <0.0001 | 5.25 | 1.63–16.89 | 0.005 | 3.59 | 1.70–7.56 | 0.001 | 3.79 | 1.13–12.78 | 0.031 |
All variables with a p value inferior to 0.1 at univariate and multi appear in bold character.
ACCI, age-adjusted Charlson comorbidity index; BMI, body mass index; CI, confidence interval; CSS, cancer-specific survival; DFS, disease-free survival; HR, hazard ratio; NACT, neoadjuvant chemotherapy; OS, overall survival.