Table 7.

Effect of P. ginseng on the pharmacokinetics of aconitine at day 7 after administration.

Aconitine	Control	P. ginseng-low	P. ginseng-middle	P. ginseng-high
AUC(0-t) (μg/L∗h)	40.77 ± 9.71	58 ± 13.02	61.05 ± 12.82∗	162.98 ± 48.50∗∗
AUC(0-∞) (μg/L∗h)	46.20 ± 9.57	60.32 ± 12.99	61.49 ± 13.16∗	228.56 ± 100.03∗∗
t1/2z (h)	10.71 ± 4.78	10.10 ± 3.72	6.14 ± 1.18	26.49 ± 23.27
Tmax (h)	2.67 ± 2.91	4.00 ± 3.27	2.11 ± 2.97	1.33 ± 0.41
Vz/F (L/kg)	3345.75 ± 1370.68	2480.3 ± 944.53	1458.36 ± 189.64∗∗	1547.04 ± 685.53∗∗
CLz/F (L/h/Kg)	225.85 ± 54.74	172.11 ± 35.46∗	169.57 ± 40.27∗∗	51.09 ± 21.00∗∗
Cmax (μg/L)	3.88 ± 0.92	5.03 ± 3.02	5.79 ± 2.80	11.53 ± 3.49∗∗

Note: Compared with the control group, ^∗P<0.05, ^∗∗P<0.01.