Table 1.
Description of features used in classification
| Feature name | Descriptiona |
|---|---|
| GScore | Grantham score |
| BScore | Amino acid score in BLOSUM62 matrix |
| Score1 | PSIC score (Sunyaev et al., 1999) for wild‐type amino acid residue (before substitution) |
| dScore | Difference of PSIC (Sunyaev et al., 1999) scores for two amino acid residue variants (before and after substitution) |
| Nobs | Number of residues observed at the substitution position in multiple alignment (without gaps) |
| NormASA | Normalized accessible protein surface area |
| dVol | Change in residue side chain volume |
| dProp | Change in solvent accessible surface propensity resulting from the substitution |
| B.fact | Normalized B‐factor (temperature factor; Chasman & Adams, 2001) for the residue |
| IdPmax | Maximum congruency of the mutant amino acid residue to all sequences in multiple alignment |
| IdQmin | Query sequence identity with the closest homolog deviating from the wild‐type amino acid residue |
| PDB_id | Availability of PDB (Berman et al., 2000) protein structure identifier |
| Transv | Substitution type (transversion or transition) |
| PfamHit | Availability of Pfam (Finn et al., 2016) protein structure identifier |
a
A more detailed description is available at http://genetics.bwh.harvard.edu/pph2/dokuwiki/appendix_a.