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. 2018 Dec 24;16:371. doi: 10.1186/s12967-018-1748-4

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Meta-analysis of the effects of intermittent energy restriction versus continuous energy restriction on triglycerides (a), total cholesterol (b), HDL-cholesterol (c) and LDL-cholesterol (d) values. MD (mean difference) indicates the mean difference on change from baseline of the IER vs. the CER arms. The plotted points are the mean differences and the horizontal error bars represent the 95% confidence intervals. The grey areas are proportional to the weight of each study in the random-effects meta-analysis. The vertical dashed line represents the pooled point estimate of the mean difference. The solid black line indicates the null hypothesis (MD = 0)