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. 2018 Dec 2;2018:4138560. doi: 10.1155/2018/4138560

Figure 2.

Figure 2

Systemic depletion of kallistatin exacerbates aortic senescence. (a) Kallistatin depletion identified by genotyping with the expression of loxp, wild-type (WT) and deletion (del) alleles. (b) Western blot analysis of mouse kallistatin expression in the kidney of WT mice and KS−/− mice. (c) Representative images and quantitative analysis of β-gal staining of aorta sections from WT, KS−/− mice with or without STZ treatment. (d, e) PAI-1 and P16INK4a mRNA levels in mouse aorta. Values are expressed as mean ± SEM. n = 3. ∗P < 0.05 vs. the WT group, #P < 0.05 vs. the WT + STZ group.