Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Signaling pathways of kallistatin in protection against vascular senescence, oxidative stress, and inflammation in EPCs and endothelial cells. Kallistatin via its heparin-binding site blocks TNF-α/H2O2-modulated NADPH oxidase activity and ROS formation and thus ICAM-1 and PAI-1/p16INK4a expression. Kallistatin through its active site stimulates Let-7g synthesis, to inhibit miR-34 and stimulate SIRT1-eNOS pathway, thereby elevating NO levels, further leading to reduced ROS levels.
