Figure 5.

Plasma miRNAs can be used to identify doxorubicin response in treated animals. Multidimensional scaling analysis was used to investigate whether the expression of regulated plasma miRNAs could be used to correctly identify treated animals showing different cardiac responses to doxorubicin. (a) All Tox miRNAs were used for unsupervised clustering. A good accuracy was observed in separating the three groups of animals. (b) We identified a restricted miRNA cluster (miR-1-3p, miR-34a-5p, miR-133a-3p, and miR-499a-5p) correctly separating Tox/NoTox mice. Blue: CTRL; green: NoTox; red: Tox. aSI: average silhouette index. CTRL n = 10; NoTox n = 5; Tox n = 4.