Table 1.
Publication | Age (years) | Sex | Neurological symptoms on admission | Imaging | Mg | Na | Ca | K | PTH | Etiology | Follow-up |
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[4] | 78 | M | PDBN | CCT: n MRI: cerebrovascular chronic ischemia and slight cerebral and cerebellar atrophy |
Not detectable | n | ↓ | n | N/A | Probably attacks of diarrhea caused by diverticulitis | PDBN disappeared after two weeks. A temporary reoccurrence was observed on day 17 |
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[12] | 61 | F | Ataxia, paresthesia, cognitive impairment | Brain and cord MRI: n | 1.5 mEq/l | N/A | N/A | N/A | N/A | TRPM6 mutation | Reoccurrence after 2 months |
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[8] | 72 | M | Severe dysarthria, ataxia, dysphagia, nystagmus | MRI: hyperintensities within both cerebellar hemispheres similar to PRES | 0.15 mmol/l | N/A | ↓ | N/A | ↑ | Short bowel syndrome after surgical treatment of adenocarcinoma and diarrhea | MRI and clinic were unremarkable after 2 months |
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[11] | 68 | F | Seizure, PDBN | MRI: a lesion within the cerebellar nodulus | 7 mg/l (range: 18–24 mg/l) | n | ↓ | ↓ | ↑ | Undetermined | Reoccurrence after 2 months |
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[7] | 59 | M | Ataxia, vertical nystagmus, seizures, PDBN | MRI: hyperintensity and swelling of the cerebellar nodulus | <0.08 mmol/l (normal range: 0.75–1.0 mmol/l) | ↓ | ↓ | ↓ | N/A | Short bowel syndrome after ileostomy due to ulcerative colitis | N/A |
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[16] | 66 | F | Dysphagia, diplopia, vertical nystagmus, weakness, cognitive impairment | N/A | 0.21 mEq/l (range: 1.4–2.0 mEq/l) | n | n | n | N/A | Short bowel syndrome after colectomy due to metastases of cervix carcinoma | Symptoms improved, dysphagia resolved after 2 months |
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[17] | 67 | F | PDBN, ataxia | N/A | 1.1–1.4 mmol/l (range: 1.5–2.5 mmol/l) | N/A | ↓ | N/A | N/A | Side effect of lithium carbonate | Symptoms resolved in 4 months |
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[5] | 21 | M | PDBN, ataxia, dysphagia, tachycardia, seizures | CCT: n | <1 mg/dl | N/A | N/A | ↓ | N/A | Parenteral nutrition, short bowel syndrome after ileocolectomy for Crohn's disease | Complete recovery after 6 weeks |
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[5] | 44 | F | Seizures, PDBS | CCT: n | 0.9 mg/ml (range: 1.5–3.5 mg/dl) | N/A | ↓ | ↓ | N/A | Parenteral nutrition, resection of terminal ileum and cecum because of metastatic fallopian adenocarcinoma | Persistence of downbeat nystagmus; death because of cancer complications after 3 months |
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[9] | 57 | M | Seizure, dysarthria, ataxia | MRI: hyperintense lesions in both cerebellar hemispheres and the vermis resembling PRES | 0.19 mmol/l | N/A | N | ↓ | N/A | Alcohol abuse | Significant improvement after 6 months |
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[18] | 65 | M | Ataxia, cognitive impairment, seizure | MRI: hyperintensities within the cerebellar vermis | 0.08 mmol/l (range: 0.7–0.9 mmol/l) | N/A | ↓ | ↓ | ↓↓↓ | Pantoprazole | Mild memory deficit is still observed after 6 months |
M: male; F: female; PDBN: paroxysmal downbeat nystagmus; n: normal; N/A: not available; Mg: magnesium; Ca: calcium; K: potassium; PTH: parathormone hormone; MRI: magnetic resonance imaging; CCT: cranial computed tomography. mEq/l: milliequivalents per liter; mmol/l: millimoles per liter; mg/dl: milligrams per deciliter; mg/ml: milligrams per milliliter. ↓: low; ↓↓↓: very low; ↑: high.