Table 3.
Univariate analysis of disease-free survival and overall survival.
| Variable | n (%) (n=484) | Disease-free survival | Overall survival | ||
|---|---|---|---|---|---|
| 5-year DFS% (95% CI) | p value∗∗ | 5-year OS% (95% CI) | p value∗∗ | ||
| Age | 0.024 | 0.448 | |||
| <50 years | 170 (35.1) | 86.6 (79.1–91.5) | 97.9 (91.6–99.5) | ||
| ≥50 years | 314 (64.9) | 89.2 (84.6–92.5) | 96.5 (92.8–98.3) | ||
| Stage | 0.066 | 0.238 | |||
| IA2 | 45 (9.3) | 97.1 (81.4–99.6) | 100 | ||
| IB1 | 439 (90.7) | 87.5 (83.3–90.6) | 96.7 (93.7–98.3) | ||
| Histology | <0.001 | 0.644 | |||
| Squamous carcinoma | 285 (58.9) | 91.1 (86.5–94.2) | 96.6 (92.6–98.5) | ||
| Adenocarcinoma | 158 (32.6) | 90.1 (83.2–94.3) | 98.8 (91.7–99.8) | ||
| Adenosquamous carcinoma | 28 (5.8) | 63.8 (36.7–81.7) | 95.0 (69.5–99.3) | ||
| Others | 13 (2.7) | 56.3 (24.4–79.1) | 85.7 (33.4–97.9) | ||
| Tumor size | 0.072 | 0.125 | |||
| ≤2 cm | 326 (67.4) | 91.1 (86.9–94.0) | 98.4 (95.2–99.5) | ||
| >2 cm | 158 (32.6) | 82.2 (73.8–88.1) | 93.5 (85.9–97.1) | ||
| Lymph vascular space invasion | 0.027 | 0.404 | |||
| No | 360 (74.4) | 90.5 (86.3–93.4) | 97.6 (94.4–99.0) | ||
| Yes | 124 (25.6) | 82.1 (72.7–88.6) | 94.9 (86.9–98.1) | ||
| Deep stromal invasion | <0.001 | 0.181 | |||
| No | 359 (74.2) | 92.2 (88.4–94.8) | 97.6 (94.4–99.0) | ||
| Yes | 125 (25.8) | 76.1 (65.7–83.7) | 94.8 (86.6–98.1) | ||
| Parametrium involvement | 0.006 | 0.002 | |||
| No | 465 (96.1) | 89.4 (85.7–92.2) | 97.7 (95.0–99.0) | ||
| Yes | 19 (3.9) | 64.2 (36.9–82.1) | 80.8 (51.4–93.4) | ||
| Lymph node status | <0.001 | <0.001 | |||
| No | 460 (95.0) | 89.7 (86.0–92.4) | 98.1 (95.6–99.2) | ||
| Yes | 24 (5.0) | 61.8 (36.0–79.7) | 71.3 (39.2–88.5) | ||
| Vaginal margin | 0.007 | 0.534 | |||
| No | 466 (96.3) | 89.1 (85.3–92.0) | 97.1 (94.3–98.6) | ||
| Yes | 18 (3.7) | 70.6 (43.2–86.6) | 93.8 (63.2–99.1) | ||
| Adjuvant treatment | 0.024 | 0.201 | |||
| No | 385 (79.6) | 90.5 (86.5–93.3) | 98.2 (95.2–99.3) | ||
| Yes | 99 (20.4) | 80.7 (69.9–88.0) | 98.2 (95.2–99.3) | ||
| Hemoglobin∗ | 0.009 | 0.016 | |||
| ≥11 g/dl | 430 (89.6) | 90.0 (86.2–92.8) | 98.0 (95.2–99.2) | ||
| <11 g/dl | 50 (10.4) | 73.8 (57.3–84.8) | 86.8 (67.8–95.0) | ||
| White blood cell∗ | 0.468 | 0.892 | |||
| ≤10,000/µl | 409 (85.4) | 87.8 (83.7–91.0) | 97.2 (94.2–98.7) | ||
| >10,000/µl | 70 (14.6) | 90.5 (78.6–96.0) | 95.3 (82.4–98.8) | ||
| Platelet∗ | 0.473 | 0.926 | |||
| ≤400,000/µl | 454 (94.8) | 88.1 (84.2–91.1) | 97.1 (94.2–98.6) | ||
| >400,000/µl | 25 (5.2) | 90.2 (66.2–97.5) | 94.1 (65.0–99.2) | ||
| NLR∗ | 0.670 | 0.934 | |||
| ≤1.8 | 242 (52.4) | 89.7 (84.2–93.3) | 98.7 (94.9–99.7) | ||
| >1.8 | 220 (47.6) | 85.6 (79.3–90.1) | 94.8 (89.4–97.5) | ||
| PLR∗ | 0.780 | 0.306 | |||
| ≤119 | 231 (50.2) | 87.9 (81.7–92.1) | 96.8 (91.5–98.8) | ||
| >119 | 229 (49.8) | 87.3 (81.6–91.3) | 96.7 (92.2–98.6) | ||
∗Numbers may not sum to total because of missing data, ∗∗p value based on nonmissing data. NLR = neutrophil/lymphocyte ratio; PLR = platelet/lymphocyte ratio; DFS = disease-free survival; OS = overall survival; CI = confidence interval.