(a) Allele frequencies in LTBI cases and healthy controls and odds ratio estimates for LTBI
| SNP ID | Position1 | Location2 | HWEp | Alleles | LTBI n (%) |
Health n (%) |
OR (95% CI) |
p value |
|---|---|---|---|---|---|---|---|---|
| rs7580912 | 230216690 | Intron 2-3 | 0.1113 | A | 48 (40) | 165 (30.4) | 1.52 (1.01-2.39) | 0.0426 |
| G | 72 (60) | 377 (69.6) | ||||||
| rs7580900 | 230216669 | Intron 2-3 | 0.5446 | A | 67 (52.3) | 214 (39.5) | 1.68 (1.14-2.48) | 0.008 |
| G | 61 (47.7) | 328 (60.5) | ||||||
| rs11556887 | 230212961 | Exon 4 | 0.0593 | C | 113 (88.3) | 476 (87.8) | 0.96 (0.53-1.74) | 0.8862 |
| T | 15 (11.7) | 66 (12.2) | ||||||
| rs9061 | 230212395 | Exon 5 | 0.1272 | G | 118 (90.8) | 427 (79.4) | 0.39 (0.21-0.73) | 0.0026 ∗ |
| A | 12 (9.2) | 111 (20.6) | ||||||
| rs3820974 | 230211574 | Intron 5-6 | 0.8257 | C | 93 (71.5) | 366 (67.5) | 0.83 (0.54-1.26) | 0.3774 |
| A | 37 (28.5) | 176 (32.5) | ||||||
| rs1365776 | 230207994 | Exon 8 | 0.4341 | A | 111 (91) | 479 (89.7) | 0.86 (0.44-1.70) | 0.6708 |
| G | 11 (9) | 55 (10.3) | ||||||
| rs41309108 | 230201006 | Intron 9-10 | 0.0333 | T | 105 (80.8) | 415 (76.6) | 0.78 (0.48-1.26) | 0.3039 |
| A | 25 (19.2) | 127 (23.4) | ||||||
| rs2241525 | 230178086 | Intron 13-14 | 0.451 | G | 30 (24.6) | 93 (17.4) | 1.55 (0.97-2.47) | 0.067 |
| A | 92 (75.4) | 441 (82.6) | ||||||
| rs1135791 | 230177560 | Exon 14 | 0.4826 | T | 107 (89.2) | 472 (87.4) | 0.76 (0.41-1.43) | 0.5952 |
| C | 13 (10.8) | 68 (12.6) | ||||||
| rs10498244 | 230173117 | Intron 14-15 | 0.5064 | A | 95 (89.6) | 459 (86.6) | 0.75 (0.38-1.47) | 0.3972 |
| G | 11 (10.4) | 71 (13.4) |
1NCBI Reference Sequence: NC_000002.12. 2Based on SP110c (NCBI Reference Sequence: NM_080424.2). HWE: Hardy-Weinberg equilibrium; OR: odds ratio; CI: confidence interval; ORs are adjusted for gender. The significant ORs are shown in italic. ∗OR remains significant after Bonferroni correction.