(b) Association between SP110 SNP genotypes and TB risk in TB patients vs. LTBI cases
| SNP ID | Genotypes | Health no. (%) | LTBI No. (%) | OR (95% CI) | p value |
|---|---|---|---|---|---|
| rs7580912 | AA | 26 (43) | 129 (43) | Ref | — |
| GA | 20 (33) | 139 (47) | 1.377 (0.731-2.595) | 0.322 | |
| GG | 14 (23) | 31 (10) | 0.392 (0.179-0.86) | 0.02 | |
| rs7580900 | AA | 16 (25) | 98 (33) | Ref | — |
| GA | 29 (45) | 151 (50) | 0.863 (0.444-1.878) | 0.664 | |
| GG | 19 (30) | 50 (17) | 0.392 (0.182-0.848) | 0.017 | |
| rs11556887 | CC | 49 (77) | 248 (83) | Ref | — |
| CT | 15 (23) | 47 (16) | 0.628 (0.324-1.219) | 0.169 | |
| TT | 0 (0) | 4 (1) | >999.999 (<0.001->999.999) | 0.988 | |
| rs9061 | GG | 54 (82) | 203 (68) | Ref | — |
| AA | 0 (0) | 15 (5) | >999.999 (<0.001->999.999) | 0.974 | |
| GA | 12 (18) | 79 (27) | 1.831 (0.924-3.627) | 0.083 | |
| rs3820974 | CC | 34 (52) | 136 (45) | Ref | — |
| AA | 6 (9) | 32 (11) | 1.261 (0.483-3.293) | 0.637 | |
| CA | 25 (38) | 131 (44) | 1.31 (0.739-2.323) | 0.356 | |
| rs1365776 | AA | 52 (83) | 240 (80) | Ref | — |
| GA | 10 (16) | 51 (17) | 1.264 (0.58-2.753) | 0.556 | |
| GG | 1 (1) | 8 (3) | 2.028 (0.244-16.888) | 0.513 | |
| rs41309108 | TT | 41 (63) | 176 (59) | Ref | — |
| AA | 1 (1) | 12 (4) | 2.401 (0.3-19.219) | 0.409 | |
| TA | 23 (35) | 111 (37) | 1.096 (0.621-1.932) | 0.753 | |
| rs2241525 | GG | 36 (58) | 211 (71) | Ref | — |
| AA | 4 (7) | 12 (4) | 0.47 (0.142-1.562) | 0.218 | |
| GA | 22 (35) | 73 (25) | 0.564 (0.31-1.026) | 0.061 | |
| rs1135791 | TT | 48 (79) | 212 (71) | Ref | — |
| CC | 0 (0) | 5 (2) | >999.999 (<0.001->999.999) | 0.986 | |
| CT | 13 (21) | 82 (27) | 1.33 (0.68-2.602) | 0.404 | |
| rs10498244 | AA | 44 (83) | 215 (72) | Ref | — |
| AG | 7 (13) | 80 (27) | 2.137 (0.917-4.981) | 0.079 | |
| GG | 2 (4) | 4 (1) | 0.441 (0.074-2.62) | 0.368 |
OR: odds ratio; CI: confidence interval; ORs are adjusted for gender. The significant ORs are shown in italic.