Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
In vivo models of infection demonstrating efficacious dose of GSK1322322 at time of candidate selection and the human equivalent dose
| Strain | MIC, μg/mL | Efficacious dose, mg/kg BID | Human equivalent dose (60 kg per person), mg BID |
| H. influenzae strain H128 | 1 | 75 (rat) | 726 |
| S. pneumoniae strain Ery-2 | 0.25 | 37.5 (rat) | 363 |
| S. aureus A-24 | 4 | 75 (mouse) | 366 |
| MRSA Panton–Valentine positive strain (PVL-2) | 4 | 37.5 (mouse) | 183 |
