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. 2018 Dec 4;115(51):E12024–E12033. doi: 10.1073/pnas.1812909115

Fig. 2.

Fig. 2.

Quantitative analysis of cross-sectional T2 relaxometry and ADC values in different regions of the brain. (A) Cross-sectional T2 values for different regions of the brain in uninfected mice (n = 4), and mice day 5 p.i. (n = 5, average clinical score = 3) and day 6 p.i. (n = 4, average clinical score = 4). The olfactory bulbs show a significant increase in T2 values between uninfected and day 6 p.i. animals (Dunn’s post hoc, P = 0.025) while the striatum shows a significant increase between day 5 and day 6 p.i. animals (Dunn’s post hoc, P = 0.012). Kruskal–Wallis analysis: olfactory bulbs, P = 0.0068; cortex, P > 0.1; corpus callosum, P > 0.1; and striatum, P = 0.0022. (B) Cross-sectional ADC values for different regions of the brain in uninfected mice (n = 4) and infected mice day 5 p.i. (n = 4, average clinical score = 3) and day 6 p.i. (n = 4, average clinical score = 2). The olfactory bulbs show a significant increase in ADC values between uninfected mice and infected mice day 6 p.i. (Dunn’s post hoc, P = 0.043). Kruskal–Wallis analysis: olfactory bulbs, P = 0.022; cortex, P > 0.1; corpus callosum, P > 0.1; and striatum, P > 0.1. Error bars represent mean ± SD. Dunn’s post hoc analysis: *P < 0.05.