Fig. 6.
Longitudinal, coronal postcontrast T1-weighted images of JHU-083–treated animals. (A) Postcontrast T1-weighted images showing reversal of abnormal enhancement (solid white arrows) in the OBs, CC, and external capsules in a representative treated animal scanned on days 6, 8, and 14 p.i. (B) Quantitative decrease in percent signal enhancement for infected animals measured on day 6 and 8 p.i. (n = 7). Paired t test in the olfactory bulbs, P < 0.0001; cortex, P = 0.0038; corpus callosum, P = 0.0010; and striatum, P = 0.0017. Dashed lines denote mean ± SD for uninfected animals in a given region (olfactory bulbs 3.5 ± 2.3; cortex 2.5 ± 2.3; corpus callosum 4.0 ± 2.1; and striatum 0.75 ± 1.5). (C) Corresponding clinical scoring vs. day postinfection for the same seven animals. All animals were treated at 6:00 AM on day 6 p.i.