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. 2018 Nov 29;115(51):13099–13104. doi: 10.1073/pnas.1808137115

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Fig. 4. — Morphological evaluation of cone photoreceptors in young and old Bmal1^fl/fl and Chx10^Cre;Bmal1^fl/fl mice. Peanut agglutinin (PNA) labeling in the central retina of young (A) and old (B) Chx10^Cre;Bmal1^fl/fl mice. (C) Quantification of PNA-labeled cones of Bmal1^fl/fl and Chx10^Cre;Bmal1^fl/fl mice retinas at 3 and 26 mo of age. A significant change in the number of PNA-positive cells is observed between Bmal1^fl/fl and Chx10^Cre;Bmal1^fl/fl mice at 26 mo of age (***P < 0.001). Cone arrestin (Arr4) staining in young (D) and old (E) Chx10^Cre;Bmal1^fl/fl mice. (F) Quantification of cone arrestin staining in Bmal1^fl/fl and Chx10^Cre;Bmal1^fl/fl mice retinas at 3 and 26 mo of age. A significant change in the number of arrestin-positive cells is observed between Bmal1^fl/fl and Chx10^Cre;Bmal1^fl/fl mice at 26 mo of age (**P < 0.01). A significant reduction in the number of cones is also observed in both genotypes during aging (Bmal1^fl/fl, **P < 0.01; Chx10^Cre;Bmal1^fl/fl, ***P < 0.001). Each bar represents the mean ± SEM (n = 3 to 4).