Fig. 2.

HIV-1 TAR interactions with Tat:AFF4:P-TEFb. (A) Ribbon diagram showing an overview of the complex. (B) Surface representation of TAR (Left) and CycT1 (Right) with Coulombic surface coloring from −10 kcal/(mol$\cdot \text{e}$) (red) to 10 kcal/(mol$\cdot \text{e}$) (blue) using a dielectric constant of 4.0 in Chimera (47). (C and D) Cartoon and ball-and-stick diagram of the TAR contact site (orange and green) with Tat (red) and CycT1 (yellow). AFF4 is shown in dark blue.