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Co-treatment with cotinine plus krill oil prevented the restraint stress-induced depressive-like behavior in mice. After three-week restraint and co-treatment with vehicle (PBS), cotinine (Cot, 5 mg/kg) or krill oil (KO, 143 mg/kg), mice were tested for depressive-like behavior in the forced swim tests (5 min). (A) or the sucrose preference tests (B). *P < 0.05, **P < 0.01, ***P < 0.001.
