Skip to main content
. 2018 Dec 11;9:2881. doi: 10.3389/fimmu.2018.02881

Figure 5.

Figure 5

Additive effect of IA and IV co-administration of iSTAT3 OA-MSCs on joint protection in MIA-induced OA rats. (A) Representative micro-CT images of the femoral condyles at 4 weeks in all groups. Object volume (Obj.V) and bone surface (%) from micro-CT images of the femur (*P < 0.05, ***P < 0.001). (B,C) Histochemical analysis of femoral condyle (B) and severity scores (C) after IA and IV co-administration of iSTAT3-OA MSCs in MIA-induced OA rats. (B) OA was induced in Wistar rats by IA injection of MIA. OA Rats were injected multiple times with IA and IV co-administration of iSTAT3 OA-MSCs (3 × 105). Knee joint tissue samples were acquired at 4 weeks from wild-type (WT) rats, rats with MIA-induced OA, rats that received IV OA-MSCs, and rats that received IV iSTAT3 OA-MSCs, and were stained with H&E and Safranin O to evaluate the severity of inflammation and cartilage damage (***P < 0.001).