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. 2018 Dec 17;9:648. doi: 10.3389/fgene.2018.00648

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Copyright © 2018 Duis, Cox, Ji, Seifuddin, Lee and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Results of the full set show similar associations between increased methylation and the TT genotype for CpGs 3-5 (A). The results also highlight the similarities in DNA methylation levels between the heterozygous (CT) and protective homozygous (CC) genotypes. Methylation levels for each genotype further segregated by case status for CpG-3 (B), CpG-4 (C), and CpG-5 (D) show a pronounced increase in methylation in the TT genotype in the cases compared to controls. The bar graphs are represented as mean ± SEM. For both the boxplots and the bar graphs, ^∗ and ^∗∗ indicates P-values < 0.05 and < 0.01, respectively, in mean methylation difference between TT and CT+CC genotypes for each CpG.