Table 2.
Blood protein levels of AD patients and control subjects.
| Data conversion | AD (n = 98) | Controls (n = 101) | t-Test | P-value | |
|---|---|---|---|---|---|
| G-CSF (pg/ml) | Ln (x+1) | 3.510 ± 1.166 | 3.052 ± 1.097 | 2.584 | 0.005** |
| IL-10 (pg/ml) | Ln (x+1) | 1.039 ± 0.800 | 0.759 ± 0.730 | 2.578 | 0.011* |
| MCP (pg/ml) | Ln (x+1) | 1.106 ± 1.715 | 1.100 ± 1.768 | 0.026 | 0.980 |
| IL-1a (pg/ml) | Ln (x+1) | 2.044 ± 1.567 | 1.659 ± 1.578 | 1.726 | 0.086 |
| IL-3 (pg/ml) | Ln (x+1) | 0.239 ± 0.276 | 0.147 ± 0.143 | 2.953 | 0.004** |
| IL-8 (pg/ml) | Ln (x+1) | 1.896 ± 1.260 | 1.726 ± 1.205 | 0.972 | 0.332 |
| MIP (pg/ml) | Ln (x+1) | 0.511 ± 0.811 | 0.528 ± 0.825 | -0.152 | 0.880 |
| IGFBP-2 (ng/ml) | Ln (x+1) | 4.933 ± 1.085 | 4.122 ± 1.090 | 5.263 | 0.000*** |
| IGFBP-6 (ng/ml) | Ln (x) | 6.179 ± 0.461 | 6.169 ± 0.502 | 0.137 | 0.891 |
| B-2 Microglobulin (ng/ml) | Ln (x) | 8.064 ± 0.874 | 7.529 ± 0.770 | 4.580 | 0.000*** |
| Clusterin (ng/ml) | SQRT (x) | 878.97 ± 162.09 | 729.87 ± 183.25 | 6.069 | 0.000*** |
| Cystatin C (ng/ml) | SQRT (x) | 30.248 ± 7.670 | 23.610 ± 8.306 | 5.852 | 0.000*** |
| PP (pg/ml) | Ln (x) | 4.802 ± 0.971 | 4.667 ± 0.791 | 1.084 | 0.280 |
| TNFa (pg/ml) | SQRT (x) | 2.778 ± 0.731 | 2.622 ± 0.724 | 1.511 | 0.132 |
| MMP-2 (pg/ml) | Ln (x) | 12.046 ± 0.286 | 11.976 ± 0.232 | 1.882 | 0.061 |
| MMP-9 (pg/ml) | Ln (x) | 10.37 ± 0.700 | 10.55 ± 0.589 | -1.927 | 0.055 |
| CP (ng/ml) | SQRT (x) | 551.21 ± 229.25 | 557.25 ± 196.47 | -0.200 | 0.842 |
| AGP (ng/ml) | Ln (x) | 13.155 ± 1.944 | 13.475 ± 1.200 | -1.394 | 0.163 |
| HP (ng/ml) | SQRT (x) | 1434.3 ± 926.7 | 1714.9 ± 1025.6 | -2.023 | 0.044* |
| sSOD1 (ng/ml) | Ln (x) | 5.440 ± 0.656 | 5.443 ± 0.498 | -0.031 | 0.975 |
| AGT (ng/ml) | Ln (x) | 4.476 ± 1.993 | 6.470 ± 1.729 | -7.544 | 0.000*** |
| Fetuin A (ng/ml) | SQRT (x) | 371.97 ± 45.32 | 377.39 ± 55.23 | -0.755 | 0.451 |
| sSOD2 (ng/ml) | Ln (x) | 3.773 ± 0.476 | 3.640 ± 0.352 | 2.232 | 0.027* |
| Contactin-1 (ng/ml) | SQRT (x) | 11.44 ± 1.982 | 11.29 ± 1.570 | 0.592 | 0.554 |
| Kallikrein-6 (ng/ml) | SQRT (x) | 2.806 ± 0.628 | 2.555 ± 0.452 | 3.252 | 0.001** |
| OPN (ng/ml) | SQRT (x) | 7.060 ± 1.489 | 5.874 ± 1.248 | 6.098 | 0.000*** |
| a2-Macroglobulin (ng/ml) | SQRT (x) | 1299.5 ± 304.59 | 1146.9 ± 329.78 | 3.388 | 0.001** |
| APO A1 (ng/ml) | SQRT (x) | 625.61 ± 175.59 | 609.57 ± 250.79 | 0.521 | 0.603 |
| APO CIII (ng/ml) | SQRT (x) | 411.28 ± 113.22 | 368.82 ± 137.12 | 2.385 | 0.018* |
| APO E (ng/ml) | SQRT (x) | 289.40 ± 71.73 | 253.24 ± 90.32 | 3.133 | 0.002** |
| Complement C3 (ng/ml) | SQRT (x) | 184.42 ± 76.35 | 208.99 ± 73.32 | -2.331 | 0.021* |
| Prealbumin (ng/ml) | SQRT (x) | 457.61 ± 113.94 | 411.31 ± 128.43 | 2.687 | 0.008** |
| Complement factor H (ng/ml) | SQRT (x) | 583.95 ± 115.00 | 502.41 ± 165.47 | 4.047 | 0.000*** |
| CRP (ng/ml) | Ln (x) | 9.255 ± 2.643 | 9.580 ± 1.352 | -1.086 | 0.279 |
| A1-Antitrypsin (ng/ml) | Ln (x) | 7.649 ± 1.340 | 8.151 ± 1.190 | -2.792 | 0.006** |
| PEDF (ng/ml) | SQRT (x) | 61.96 ± 23.23 | 63.61 ± 17.57 | -0.565 | 0.572 |
| SAP (ng/ml) | Ln (x) | 10.812 ± 2.551 | 11.656 ± 1.368 | -2.921 | 0.004** |
| MIP-4 (ng/ml) | Ln (x) | 4.140 ± 0.784 | 4.011 ± 0.637 | 1.277 | 0.203 |
| Complement C4 (ng/ml) | SQRT (x) | 156.81 ± 72.86 | 116.06 ± 49.76 | 4.594 | 0.000*** |
| BDNF (pg/ml) | Ln (x) | 8.006 ± 1.219 | 6.818 ± 0.942 | 7.705 | 0.000*** |
| Cathepsin D (pg/ml) | SQRT (x) | 608.92 ± 178.92 | 479.43 ± 154.10 | 5.476 | 0.000*** |
| sICAM-1 (pg/ml) | SQRT (x) | 365.19 ± 69.65 | 300.29 ± 84.30 | 5.910 | 0.000*** |
| MPO (pg/ml) | SQRT (x) | 12.080 ± 1.491 | 11.519 ± 1.494 | 2.649 | 0.009** |
| PDGF-AA (pg/ml) | Ln (x) | 7.212 ± 0.969 | 6.322 ± 0.756 | 7.206 | 0.000*** |
| RANTES (pg/ml) | Ln (x) | 10.122 ± 1.025 | 9.138 ± 1.030 | 6.751 | 0.000*** |
| NCAM (pg/ml) | SQRT (x) | 608.35 ± 96.051 | 505.86 ± 126.59 | 6.446 | 0.000*** |
| PDGF-AB/BB (pg/ml) | Ln (x) | 8.270 ± 1.161 | 7.789 ± 0.621 | 7.185 | 0.000*** |
| sVCAM-1 (pg/ml) | SQRT (x) | 956.61 ± 185.54 | 778.87 ± 215.38 | 6.215 | 0.000*** |
| PAI-1 Total (pg/ml) | SQRT (x) | 366.67 ± 117.04 | 331.95 ± 124.71 | 2.024 | 0.044* |
| HSA (μg/ml) | SQRT (x) | 208.60 ± 40.69 | 192.74 ± 51.37 | 2.410 | 0.017* |
Significant P-value (∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001).