Table 3.
Levels of proinflammatory cytokines in LPS-stimulated primary human macrophages
| Control | DM2 | DPN | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| Nonstimulated | LPS | Nonstimulated | LPS | Nonstimulated | LPS | |
| Cytokines | ||||||
| TNF-α | 4.8±1.6 | 1,150±583.8* | 4.6±3 | 572.2±311.9* | 5.4±2 | 442.7±248.2* |
| MCP-1 | 25,448±19,836 | 69,304±23,016* | 16,200±14,076 | 40,324±16,558* | 10,149±4,566 | 43,592±25,168* |
| IL-6 | 605.3±312.1 | 19,740±2,769* | 1,612±778.8 | 8,466±7,239* | 646.7±512.5 | 8,126±8,084* |
Note:
*
P<0.05 vs their respective nonstimulated group.
Abbreviations: DM2, diabetes mellitus type 2; DPN, diabetic peripheral neuropathy; LPS, lipopolysaccharide; TNF-α, tumor necrosis factor-alpha; MCP-1, monocyte chemoattractant protein-1.