Table 4.
Levels of anti-inflammatory cytokines in CD163-overexpressing primary human macrophages
| Cytokines | Experiment | Control | DM2 | DPN | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||||
| pEmpty | pCD163 | P-value | n | pEmpty | pCD163 | P-value | n | pEmpty | pCD163 | P-value | n | ||
|
| |||||||||||||
| IL-10 | #1 | 1,912±2,146 | 1,066±869.5 | 0.65 | 2 | 426.7±27.4 | 232.1±63 | 0.057 | 2 | 933.8±418.9 | 564±329.3 | 0.12 | 6 |
| #2 | 379.1±267.4 | 283.2±195.9 | 0.58 | 4 | 443.4±66.5 | 184.1±30.1 | 0.008 | 3 | 107.8±1.08 | 61.9±13.7 | 0.04 | 2 | |
| #3 | 51.8±18.9 | 57.2±27.9 | 0.84 | 2 | 40.1±1.1 | 42.9±7.7 | 0.65 | 2 | 80.2±7.4 | 64.7±3.1 | 0.11 | 2 | |
| TGF-β | #1 | 6,501±2,343 | 6,809±1,655 | 0.89 | 2 | 7,223±2,360 | 6,984±3,352 | 0.91 | 4 | 5,332±281.7 | 6,301±1,383 | 0.16 | 6 |
| #2 | 661.3±10.55 | 637.2±60.27 | 0.53 | 3 | 678.4±14.6 | 663.3±23.4 | 0.39 | 3 | 663.5±6.9 | 673.2±19.8 | 0.46 | 3 | |
| #3 | 835.4±197.3 | 779.7±442.1 | 0.82 | 3 | 112.2±20.2 | 137.1±14.7 | 0.29 | 2 | 237.5±62.5 | 306.9±130.6 | 0.44 | 4 | |
| sCD163 | #1 | 2,334±70 | 2,290±199.6 | 0.73 | 3 | 2,442±239.8 | 2,533±323.7 | 0.71 | 3 | 2,269±88.28 | 2,454±60.03 | 0.85 | 3 |
| #2 | 2,701±543.1 | 2,624.7±157 | 0.37 | 2 | 2,672±480.8 | 2,596±432.3 | 0.82 | 4 | 2,325±21.5 | 2,198±91.9 | 0.14 | 2 | |
| #3 | 2,737±199.9 | 3,104±408.9 | 0.21 | 3 | 2,471±42.9 | 3,308±735.8 | 0.22 | 2 | 2,174±71.2 | 2,458±519.8 | 0.52 | 2 | |
Abbreviations: DM2, diabetes mellitus type 2; DPN, diabetic peripheral neuropathy; TNF-α, tumor necrosis factor-alpha.