Table 1. Cellular metabolite concentrations from 1D-NMR spectra.
Metabolite | Cellular Metabolite Concentrations
(mM/mg of protein) |
|||||
---|---|---|---|---|---|---|
Control | FK866 | FK866 NR | ||||
Mean | SEM | Mean | SEM | Mean | SEM | |
1,3-Dimethylurate | 0.00 | 0.03 | 0.00 | 0.01 | 0.00 | 0.01 |
1,7-Dimethylxanthine | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.05 |
2-Aminoadipate | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 |
2-Aminobutyrate | 0.06 | 0.08 | 0.06 | 0.08 | 0.07 | 0.07 |
2-Hydroxyisobutyrate | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 |
2-Hydroxyisocaproate | 0.02 | 0.08 | 0.04 | 0.06 | 0.03 | 0.05 |
2-Oxoisocaproate | 0.00 | 0.02 | 0.00 | 0.01 | 0.00 | 0.01 |
3-Hydroxyisovalerate | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
3-Methyl-2-oxovalerate | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 |
Acetoacetate | 0.01 | 0.01 | 0.01 | 0.02 | 0.01 | 0.01 |
Alanine | 0.07 | 0.12 | 0.08 | 0.10 | 0.09 | 0.15 |
Arabinose | 0.03 | 0.05 | 0.04 | 0.22 | 0.04 | 0.04 |
Asparagine | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | 0.01 |
Choline | 0.01 | 0.02 | 0.01 | 0.01 | 0.01 | 0.02 |
Citrate | 0.01 | 0.02 | 0.01 | 0.02 | 0.02 | 0.02 |
Dimethylamine | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 |
Fumarate | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
Galactarate | 0.01 | 0.03 | 0.02 | 0.03 | 0.01 | 0.03 |
Glucose | 0.00 | 0.01 | 0.14 | 0.01 | 0.01 | 0.09 |
Glutathione | 0.05 | 0.06 | 0.05 | 0.06 | 0.06 | 0.06 |
Glycine | 0.08 | 0.18 | 0.11 * | 0.21 | 0.15 | 0.20 |
Hydroxyacetone | 0.01 | 0.02 | 0.01 | 0.02 | 0.02 | 0.02 |
Imidazole | 0.00 | 0.02 | 0.01 | 0.00 | 0.00 | 0.01 |
Nicotinamide N-oxide | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
O-Acetylcarnitine | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.01 |
O-Acetylcholine | 0.01 | 0.02 | 0.01 | 0.02 | 0.01 | 0.01 |
Phenylalanine | 0.04 | 0.12 | 0.05 | 0.10 | 0.03 | 0.09 |
Pyruvate | 0.01 | 0.01 | 0.01 | 0.02 | 0.01 | 0.02 |
Succinate | 0.00 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 |
Taurine | 0.26 | 0.45 | 0.29 * | 0.47 | 0.22 | 0.51 |
Threonine | 0.07 | 0.09 | 0.09 * | 0.24 | 0.07 | 0.09 |
Tryptophan | 0.01 | 0.02 | 0.01 | 0.01 | 0.01 | 0.02 |
Tyrosine | 0.05 | 0.16 | 0.08 | 0.14 | 0.04 | 0.12 |
Valine | 0.06 | 0.20 | 0.10 | 0.18 | 0.06 | 0.16 |
* p<0.05; Two-way ANOVA performed on all data; Dunnett’s multiple comparison test. n=6.